Synthesis and reactivity of unique heterocyclic structures en route to substituted diamines

Org Lett. 2011 Jul 1;13(13):3336-9. doi: 10.1021/ol2010769. Epub 2011 May 27.

Abstract

Rhodium-catalyzed oxidative cyclization of allylic hydroxylamine-derived sulfamate esters furnishes a novel family of bicyclic aziridines that serve as functional precursors to substituted diamines. Investigations with the N4-Troc form of these heterocycles have led to manifold improvements in reaction performance and scope and have revealed unique differences in the stability and reactivity of such compounds dictated by the choice of N4-protecting group.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aziridines / chemistry
  • Catalysis
  • Diamines / chemistry*
  • Heterocyclic Compounds / chemical synthesis*
  • Molecular Structure
  • Oxidation-Reduction
  • Stereoisomerism

Substances

  • Aziridines
  • Diamines
  • Heterocyclic Compounds
  • aziridine