Abstract
A new drimane sesquiterpenoid glycoside, named 7-drimen-3β,11-diol 3-O-β-d-glucopyranoside, was isolated from the 95% EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. The chemical structure was completely elucidated using a combination of 1D and 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analysis. The compound showed inhibitory activities toward methicillin-resistant Staphylococcus aureus (MRSA), chronic myelogenous leukemia (K562), and human hepatoma (SMMC-7721) cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents
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Antiaris / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Humans
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K562 Cells
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Polycyclic Sesquiterpenes
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Seeds / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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7-drimen-3beta,11-diol 3-O-beta-D-glucopyranoside
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Anti-Infective Agents
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Glucosides
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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drimane