We introduce a comprehensive theoretical framework for the fermionic superfluid dynamics, grounded on a local extension of the time-dependent density functional theory. With this approach, we describe the generation and the real-time evolution and interaction of quantized vortices, the large-amplitude collective modes, as well as the loss of superfluidity at high flow velocities. We demonstrate the formation of vortex rings and provide a microscopic description of the crossing and reconnection of quantized vortex lines in a fermion superfluid, which provide the mechanism for the emergence of quantum turbulence at very low temperatures. We observe that superfluidity often survives when these systems are stirred with velocities far exceeding the speed of sound.