Mediastinal involvement in lymphangiomatosis: a previously unreported MRI sign

Pediatr Radiol. 2011 Aug;41(8):985-92. doi: 10.1007/s00247-011-2124-1. Epub 2011 Jun 10.

Abstract

Background: Multifocal lymphangiomatosis is a rare systemic disorder affecting children. Due to its rarity and wide spectrum of clinical, histological and imaging features, establishing the diagnosis of multifocal lymphangiomatosis can be challenging.

Objectives: The purpose of this study was to describe a new imaging sign in this disorder: paraspinal soft tissue and signal abnormality at MRI.

Materials and methods: We retrospectively reviewed the imaging, clinical and histopathological findings in a cohort of eight children with thoracic involvement from this condition.

Results: Evidence of paraspinal chest disease was identified at MRI and CT in all eight of these children. The changes comprise heterogeneous intermediate-to-high signal parallel to the thoracic vertebrae on T2-weighted sequences at MRI, with abnormal paraspinal soft tissue at CT and plain radiography.

Conclusion: Multifocal lymphangiomatosis is a rare disorder with a broad range of clinicopathological and imaging features. MRI allows complete evaluation of disease extent without the use of ionising radiation and has allowed us to describe a previously unreported imaging sign in this disorder, namely, heterogeneous hyperintense signal in abnormal paraspinal tissue on T2-weighted images.

MeSH terms

  • Child
  • Child, Preschool
  • Cohort Studies
  • Contrast Media
  • Diagnosis, Differential
  • Female
  • Humans
  • Image Enhancement / methods
  • Infant
  • Lymphangioma / diagnostic imaging
  • Lymphangioma / pathology*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Mediastinal Neoplasms / diagnostic imaging
  • Mediastinal Neoplasms / pathology*
  • Mediastinum / diagnostic imaging
  • Mediastinum / pathology
  • Meglumine
  • Organometallic Compounds
  • Retrospective Studies
  • Tomography, X-Ray Computed / methods

Substances

  • Contrast Media
  • Organometallic Compounds
  • Meglumine
  • gadoterate meglumine