The United States of histone ubiquitylation and methylation

Michael Werner; Alexander J Ruthenburg

doi:10.1016/j.molcel.2011.06.015

The United States of histone ubiquitylation and methylation

Mol Cell. 2011 Jul 8;43(1):5-7. doi: 10.1016/j.molcel.2011.06.015.

Authors

Michael Werner¹, Alexander J Ruthenburg

Affiliation

¹ Department of Molecular Genetics and Cell Biology, University of Chicago, 920 East 58(th) St., Chicago, IL 60637, USA.

PMID: 21726805
DOI: 10.1016/j.molcel.2011.06.015

Abstract

In this issue of Molecular Cell, Wu et al. (2011) reveal that ubiquitylation of histone 2B lysine 34 stimulates histone methyltransferase activity on nucleosomes, a finding with implications for the general mechanism by which monoubiquitylation may influence subsequent modification activities.

Publication types

Comment

Grants and funding

T32 GM007183/GM/NIGMS NIH HHS/United States