Epidermal growth factor increases cyclic AMP levels in pregnant rat mammary gland explants

Res Commun Chem Pathol Pharmacol. 1990 Sep;69(3):317-23.

Abstract

Addition of epidermal growth factor (EGF) to a rat mammary organ culture results in increase levels of intracellular cyclic AMP. This dose dependent EGF effect occurs at physiological concentrations of the hormone and was maximal in early and middle pregnancy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cyclic AMP / metabolism*
  • Epidermal Growth Factor / pharmacology*
  • Female
  • Lactation / physiology
  • Mammary Glands, Animal / metabolism*
  • Organ Culture Techniques
  • Pregnancy
  • Pregnancy, Animal / metabolism*
  • Rats
  • Rats, Inbred Strains

Substances

  • Epidermal Growth Factor
  • Cyclic AMP