Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin

Dubert M Guerrero; Christina Chou; Lucy A Jury; Michelle M Nerandzic; Jennifer C Cadnum; Curtis J Donskey

doi:10.1093/cid/cir361

Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin

Clin Infect Dis. 2011 Aug 1;53(3):287-90. doi: 10.1093/cid/cir361.

Authors

Dubert M Guerrero¹, Christina Chou, Lucy A Jury, Michelle M Nerandzic, Jennifer C Cadnum, Curtis J Donskey

Affiliation

¹ Department of Infectious Diseases, University Hospitals of Cleveland, OH, USA.

PMID: 21765078
DOI: 10.1093/cid/cir361

Abstract

In a prospective study of 132 patients with a diagnosis of Clostridium difficile infection (CDI) by polymerase chain reaction, 43 (32%) had enzyme immunoassay (EIA) results negative for toxin. EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores.

Publication types

Comparative Study
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adult
Aged
Aged, 80 and over
Bacterial Toxins / analysis*
Clostridioides difficile / isolation & purification*
Clostridioides difficile / pathogenicity*
Clostridium Infections / diagnosis*
Clostridium Infections / pathology*
Clostridium Infections / prevention & control
Clostridium Infections / transmission
Female
Humans
Immunoenzyme Techniques
Infection Control / methods*
Male
Middle Aged
Polymerase Chain Reaction
Prospective Studies

Substances

Bacterial Toxins