Abstract
No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoembryonic Antigen / analysis
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Cisplatin / administration & dosage
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Female
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Humans
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Immunohistochemistry
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Mitomycin
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Mitomycins / administration & dosage
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Paget Disease, Extramammary / drug therapy*
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Paget Disease, Extramammary / immunology
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Paget Disease, Extramammary / pathology
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Vincristine / administration & dosage
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Vulvar Neoplasms / drug therapy*
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Vulvar Neoplasms / immunology
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Vulvar Neoplasms / pathology
Substances
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Carcinoembryonic Antigen
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Mitomycins
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Mitomycin
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Vincristine
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Cisplatin