A TeNaCious foundation for the metastatic niche

Irina Matei; Cyrus M Ghajar; David Lyden

doi:10.1016/j.ccr.2011.08.004

A TeNaCious foundation for the metastatic niche

Cancer Cell. 2011 Aug 16;20(2):139-41. doi: 10.1016/j.ccr.2011.08.004.

Authors

Irina Matei¹, Cyrus M Ghajar, David Lyden

Affiliation

¹ Departments of Pediatrics and Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.

PMID: 21840480
DOI: 10.1016/j.ccr.2011.08.004

Abstract

In the July issue of Nature Medicine, Massagué and colleagues define a biphasic role for the extracellular matrix protein tenascin C as a metastatic niche component in lung colonization by breast cancer cells. These results provide a rationale for designing therapies targeting metastatic progression by disrupting its very foundations.