Selection of an M184V mutation in the cerebrospinal fluid of a treatment-naive HIV-infected individual starting darunavir-based therapy

Antivir Ther. 2011;16(6):931-5. doi: 10.3851/IMP1781.

Abstract

Here, we describe a newly diagnosed HIV-1-infected patient, in whom shortly after the initiation of a darunavir-based regimen, the HIV-1 virus exclusively mutated in the cerebrospinal fluid (CSF), leading to an increase in CSF HIV-1 RNA load and neurological complaints.

Publication types

  • Case Reports

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Darunavir
  • Drug Resistance, Viral / genetics
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / classification
  • HIV-1 / drug effects
  • HIV-1 / genetics*
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Phylogeny
  • RNA, Viral / cerebrospinal fluid*
  • Sulfonamides / therapeutic use*
  • Viral Load
  • pol Gene Products, Human Immunodeficiency Virus / genetics*

Substances

  • Anti-HIV Agents
  • RNA, Viral
  • Sulfonamides
  • pol Gene Products, Human Immunodeficiency Virus
  • Darunavir