Synaptic plasticity of feeding circuits: hormones and hysteresis

Marcelo O Dietrich; Tamas L Horvath

doi:10.1016/j.cell.2011.08.031

Synaptic plasticity of feeding circuits: hormones and hysteresis

Cell. 2011 Sep 16;146(6):863-5. doi: 10.1016/j.cell.2011.08.031.

Authors

Marcelo O Dietrich¹, Tamas L Horvath

Affiliation

¹ Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

PMID: 21925311
DOI: 10.1016/j.cell.2011.08.031

Abstract

The drive to eat is controlled by neuronal circuits in the hypothalamus that respond to hormones signaling hunger or satiety. In this issue of Cell, Yang et al. (2011) reveal an AMPK-dependent synaptic pathway that sustains excitatory stimulation of the NPY/AgRP neurons that promote feeding behavior until satiety signals kick in.

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