Identification of a novel HLA-DRB1 allele through sequence-based typing of an Italian patient candidate for kidney transplant

Tissue Antigens. 2012 Feb;79(2):141-2. doi: 10.1111/j.1399-0039.2011.01771.x. Epub 2011 Sep 22.

Abstract

In this report, we describe the identification of the novel HLA-DRB1*13:120 that differs from the closest matching allele HLA-DRB1*13:65 at two nucleotidic position in the exon 2.

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Base Sequence
  • Codon
  • Exons
  • HLA-DRB1 Chains / genetics*
  • HLA-DRB1 Chains / immunology
  • HLA-DRB1 Chains / isolation & purification
  • Histocompatibility Testing
  • Humans
  • Kidney Transplantation*
  • Male
  • Molecular Sequence Data
  • Nucleotides / genetics
  • Point Mutation
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Analysis, DNA
  • White People

Substances

  • Codon
  • HLA-DRB1 Chains
  • Nucleotides