Relapsing tumefactive lesion in an adult with medulloblastoma previously treated with chemoradiotherapy and stem cell transplant

Ali Mahta; Yan Qu; Denis Nastic; Maria Sundstrom; Ryan Y Kim; Marlon Saria; Sandro Santagata; Santosh Kesari

doi:10.1007/s12253-011-9464-x

Relapsing tumefactive lesion in an adult with medulloblastoma previously treated with chemoradiotherapy and stem cell transplant

Pathol Oncol Res. 2012 Apr;18(2):539-43. doi: 10.1007/s12253-011-9464-x. Epub 2011 Sep 28.

Authors

Ali Mahta¹, Yan Qu, Denis Nastic, Maria Sundstrom, Ryan Y Kim, Marlon Saria, Sandro Santagata, Santosh Kesari

Affiliation

¹ Department of Neurosciences, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 21953324
DOI: 10.1007/s12253-011-9464-x

Abstract

Herein, we present an adult case of medulloblastoma who received chemotherapy, radiation therapy and stem cell transplantation, and underwent multiple surgical resections for what were thought to be recurrences; however pathology confirmed a diagnosis of relapsing tumefactive lesions. This phenomenon seems to be a consequence of stem cell transplantation rather than a simple radiation treatment effect.

Publication types

Case Reports

MeSH terms

Adult
Combined Modality Therapy
Demyelinating Diseases / etiology*
Demyelinating Diseases / pathology
Humans
Male
Medulloblastoma / complications*
Medulloblastoma / therapy*
Neoplasm Recurrence, Local / etiology*
Neoplasm Recurrence, Local / pathology
Sclerosis / etiology*
Sclerosis / pathology
Stem Cell Transplantation / adverse effects*
Treatment Outcome