mTOR signaling in disease

Eva Dazert; Michael N Hall

doi:10.1016/j.ceb.2011.09.003

mTOR signaling in disease

Curr Opin Cell Biol. 2011 Dec;23(6):744-55. doi: 10.1016/j.ceb.2011.09.003. Epub 2011 Sep 29.

Authors

Eva Dazert¹, Michael N Hall

Affiliation

¹ Biozentrum, University of Basel, CH4056 Basel, Switzerland.

PMID: 21963299
DOI: 10.1016/j.ceb.2011.09.003

Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Proliferation
Disease Models, Animal
Humans
Mammals / metabolism
Neoplasms / metabolism
Signal Transduction*
TOR Serine-Threonine Kinases / metabolism*

Substances

MTOR protein, human
TOR Serine-Threonine Kinases