Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides

Chem Commun (Camb). 2012 Jan 25;48(7):961-3. doi: 10.1039/c1cc15222j. Epub 2011 Nov 3.

Abstract

Ti(4+)-EPO nanoparticles were adopted as the adsorbent for in situ solid phase enrichment and isotope labeling of endogenous phosphopeptides, which has great potential application in high-throughput analyses of biological samples for screening and discovery of disease-specific biomarkers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Base Sequence
  • Isotope Labeling / methods
  • Molecular Sequence Data
  • Nanoparticles / chemistry*
  • Phosphopeptides / chemistry*
  • Phosphopeptides / isolation & purification
  • Phosphoric Acids / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
  • Titanium / chemistry*

Substances

  • Phosphopeptides
  • Phosphoric Acids
  • Silicon Dioxide
  • Titanium
  • phosphoric acid