While delivering innovative care for over 17 million children living with and affected by HIV/AIDS is a priority for today's global health community, most of these children's health needs remain unmet. Concerns about funding, implementation, and transparency continue to obstruct quality care for all. This paper discusses why services supported by macro-level funding, local initiatives, innovative financing, and enhanced long-term development strategies, are imperative. Concurrent advocacy and preventive measures, such as universal access to education, can sustain this investment in human capital. Such efforts may enhance economic growth, expand local capacity, and improve the quality of life in communities currently burdened by the HIV epidemic.