Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

Leukemia. 2012 May;26(5):1140-3. doi: 10.1038/leu.2011.325. Epub 2011 Nov 18.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Humans
  • Janus Kinase 2 / antagonists & inhibitors*
  • K562 Cells
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Oncogene Proteins v-abl / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Oncogene Proteins v-abl
  • JAK2 protein, human
  • Janus Kinase 2