Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques

N L Letvin; N W King

Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques

J Acquir Immune Defic Syndr (1988). 1990;3(11):1023-40.

Authors

N L Letvin¹, N W King

Affiliation

¹ Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772.

PMID: 2213505

Abstract

The striking similarities between simian immunodeficiency virus (SIV)-induced disease in macaque monkeys and HIV-induced disease in humans make the SIV-induced macaque monkey an extraordinarily important model for the study of AIDS. The most significant difference between these lentivirus-induced syndromes is the more rapid progression of disease in SIV-infected monkeys. The immunologic and pathologic manifestations of SIV infections in rhesus monkeys are described.

Publication types

Comparative Study
Review

MeSH terms

Acquired Immunodeficiency Syndrome* / immunology
Acquired Immunodeficiency Syndrome* / pathology
Animals
Disease Models, Animal
Humans
Macaca mulatta*
Simian Acquired Immunodeficiency Syndrome* / etiology
Simian Acquired Immunodeficiency Syndrome* / immunology
Simian Acquired Immunodeficiency Syndrome* / pathology
Simian Immunodeficiency Virus* / immunology