Fatal parvovirus B19 myocarditis in children and possible dysimmune mechanism

Pediatr Infect Dis J. 2012 Apr;31(4):418-21. doi: 10.1097/INF.0b013e3182425786.

Abstract

We report 2 cases of previously healthy children, who developed, after a common parvovirus B19 infection, a sudden inflammatory response, involving predominantly T cell, directed against myocardium and leading to fatal outcome. These cases and several published case reports further our understanding of fulminating parvovirus myocarditis in children.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Fatal Outcome
  • Humans
  • Male
  • Myocarditis / diagnosis*
  • Myocarditis / immunology
  • Myocarditis / pathology*
  • Myocarditis / virology
  • Myocardium / immunology
  • Myocardium / pathology
  • Parvoviridae Infections / diagnosis*
  • Parvoviridae Infections / immunology
  • Parvoviridae Infections / pathology*
  • Parvoviridae Infections / virology
  • Parvovirus B19, Human / immunology
  • Parvovirus B19, Human / isolation & purification*
  • Parvovirus B19, Human / pathogenicity
  • T-Lymphocytes / immunology