Abstract
ENU mutagenesis is an efficient method to identify new animal models of ocular disease. The new alleles described herein will be a useful resource to further examine the role of the affected molecules and the effects of their disruption within the retina.
MeSH terms
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Alkylating Agents / toxicity
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Animals
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Chromosome Mapping / methods
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Cyclic Nucleotide Phosphodiesterases, Type 6 / genetics*
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DNA Mutational Analysis / methods
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Disease Models, Animal*
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Ethylnitrosourea / toxicity
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Eye Proteins / genetics*
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Humans
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Mice
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Mice, Inbred C57BL*
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Mutagenesis / physiology
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Retinal Degeneration / chemically induced
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Retinal Degeneration / genetics*
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Rhodopsin / genetics*
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Translational Research, Biomedical / methods
Substances
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Alkylating Agents
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Eye Proteins
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Tulp1 protein, mouse
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Rhodopsin
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Cyclic Nucleotide Phosphodiesterases, Type 6
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Pde6a protein, mouse
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Ethylnitrosourea