A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer

Zdenko van Kesteren; José Belderbos; Marcel van Herk; Agnieszka Olszewska; Emmy Lamers; Dirk De Ruysscher; Eugène Damen; Corine van Vliet-Vroegindeweij

doi:10.1016/j.radonc.2011.09.023

A practical technique to avoid the hippocampus in prophylactic cranial irradiation for lung cancer

Radiother Oncol. 2012 Feb;102(2):225-7. doi: 10.1016/j.radonc.2011.09.023. Epub 2011 Dec 20.

Authors

Zdenko van Kesteren¹, José Belderbos, Marcel van Herk, Agnieszka Olszewska, Emmy Lamers, Dirk De Ruysscher, Eugène Damen, Corine van Vliet-Vroegindeweij

Affiliation

¹ Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. z.vankesteren@amc.uva.nl

PMID: 22192478
DOI: 10.1016/j.radonc.2011.09.023

Abstract

A practical technique is presented to deliver hippocampus avoiding prophylactic cranial irradiation for lung cancer patients, using two lateral fields. For a prescribed dose of 12×2.5 Gy, sparing of the hippocampi to 6.1 Gy was achieved with a V95% of the brain of 81.7%.

MeSH terms

Brain Neoplasms / prevention & control*
Brain Neoplasms / secondary
Cranial Irradiation / methods*
Dose Fractionation, Radiation
Female
Hippocampus / radiation effects*
Humans
Lung Neoplasms / pathology*
Magnetic Resonance Imaging
Male
Neoplasm Staging
Organs at Risk
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods*
Tomography, X-Ray Computed