Abstract
A 6-day period of subcutaneous infusion with recombinant human insulin-like growth factor I in three healthy male volunteers resulted in an increase in the ratio of insulin to C-peptide levels and significant decreases in triglyceride levels and the ratio of total to high density lipoprotein-cholesterol in serum. Increased renal plasma flow and glomerular filtration rates were also observed.
MeSH terms
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Adult
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Blood Glucose / analysis
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C-Peptide / blood
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Growth Hormone / pharmacology
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Humans
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Injections, Subcutaneous
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Insulin / blood
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Insulin / pharmacokinetics
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Insulin-Like Growth Factor I / administration & dosage
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Insulin-Like Growth Factor I / analysis
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Insulin-Like Growth Factor I / pharmacology*
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Kidney / drug effects
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Kidney / physiology
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Male
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Recombinant Proteins / administration & dosage
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Recombinant Proteins / analysis
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Recombinant Proteins / pharmacology
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Triglycerides / blood
Substances
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Blood Glucose
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C-Peptide
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Insulin
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Recombinant Proteins
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Triglycerides
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Insulin-Like Growth Factor I
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Growth Hormone