The actual role of sodium cromoglycate in the treatment of asthma--a critical review

Sleep Breath. 2012 Dec;16(4):1027-32. doi: 10.1007/s11325-011-0639-1. Epub 2012 Jan 6.

Abstract

Introduction: Despite international consensus and clearly written guidelines urging wider use of corticosteroids or combinations of inhaled short- and long-acting β-agonists (SABA and LABA) and corticosteroids in persistent asthma, prescribing patterns and compliance rates fall far short of recommendations.

Objectives: The failure to use steroids more aggressively is due, in part, to their side effects, even with inhaled forms of the drug. There is a role for expanded use of sodium cromolyn in asthma. Its potent anti-inflammatory effects, lack of side effects, and acceptable dosing and method of delivery, as well as its special role in exercise-induced asthma, make it a very suitable choice in the initial therapy for control of asthma.

Conclusion: Compared to SABA and LABA, cromoglycates alone are unsuspicious of being used to enhance physical performance.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-2 Receptor Agonists
  • Adult
  • Anti-Asthmatic Agents / adverse effects
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / drug therapy*
  • Asthma, Exercise-Induced / drug therapy
  • Body Height / drug effects
  • Child
  • Cromolyn Sodium / adverse effects
  • Cromolyn Sodium / therapeutic use*
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Humans
  • Long-Term Care
  • Medication Adherence
  • Sympathomimetics / adverse effects
  • Sympathomimetics / therapeutic use

Substances

  • Adrenergic beta-2 Receptor Agonists
  • Anti-Asthmatic Agents
  • Delayed-Action Preparations
  • Sympathomimetics
  • Cromolyn Sodium