N-Directing group assisted rhodium-catalyzed aryl C-H addition to aryl aldehydes

Org Lett. 2012 Jan 20;14(2):636-9. doi: 10.1021/ol2032784. Epub 2012 Jan 9.

Abstract

Direct aryl C-H addition to aryl aldehydes to produce biaryl methanols was reported via Rh catalysis with an N-containing directing group. The method is highly atom-, step-, and redox-economic. The procedure is robust, reliable, and compatible with water and air.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Benzoquinones / chemistry
  • Catalysis
  • Models, Molecular
  • Molecular Structure
  • Oxidation-Reduction
  • Rhodium / chemistry*

Substances

  • Aldehydes
  • Benzoquinones
  • phenylbenzoquinone
  • Rhodium