What is active acromegaly and which parameters do we have?

Clin Endocrinol (Oxf). 2012 May;76(5):609-14. doi: 10.1111/j.1365-2265.2012.04346.x.

Abstract

Disease activity of acromegaly can be measured in many ways. Growth hormone (GH) and insulin-like growth factor 1 (IGF1) concentrations are the main biochemical markers used to measure the response to treatment. Both GH and IGF1 have been associated with prognosis, in particular mortality. In this review, we discuss the available parameters to assess disease activity in acromegaly.

Publication types

  • Review

MeSH terms

  • Acromegaly / diagnosis
  • Acromegaly / drug therapy
  • Acromegaly / metabolism*
  • Biomarkers / metabolism*
  • Human Growth Hormone / analogs & derivatives
  • Human Growth Hormone / metabolism*
  • Human Growth Hormone / therapeutic use
  • Humans
  • Insulin-Like Growth Factor I / metabolism*
  • Outcome Assessment, Health Care / methods
  • Prognosis
  • Quality of Life
  • Surveys and Questionnaires

Substances

  • Biomarkers
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • pegvisomant