Application of an indoleamine 2,3-dioxygenase-expressing skin substitute improves scar formation in a fibrotic animal model

J Invest Dermatol. 2012 May;132(5):1501-5. doi: 10.1038/jid.2011.467. Epub 2012 Feb 2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cicatrix / metabolism
  • Cicatrix / pathology*
  • Collagen Type I / genetics
  • Collagen Type I / metabolism
  • Collagen Type I, alpha 1 Chain
  • Fibroblasts
  • Gene Expression
  • Graft Survival
  • Immunologic Factors / genetics
  • Immunologic Factors / metabolism*
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / genetics
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism*
  • Matrix Metalloproteinase 1 / genetics
  • Matrix Metalloproteinase 1 / metabolism
  • Rabbits
  • Skin / metabolism*
  • Skin / pathology
  • Skin, Artificial*
  • Transduction, Genetic
  • Wound Healing*

Substances

  • Collagen Type I
  • Collagen Type I, alpha 1 Chain
  • Immunologic Factors
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Matrix Metalloproteinase 1