Objective: To investigate the occurrence of cardiotoxicity of chemotherapeutic drugs in gynecological cancer patients without heart disease, and patients with coronary heart disease or congenital heart disease for providing a basis for the clinical prevention of heart side effects during chemotherapy.
Methods: Thirty cases with gynecological cancer complication with or without coronary heart disease or congenital heart disease before or during chemotherapy admitted from Jan.2004 to Dec.2010 were retrospectively analyzed.
Results: For all 30 patients, there were heart failures in 3 cases (10%, 3/30), myocardial infarction in 3 cases (10%, 3/30), angina pectoris in 1 cases (3%, 1/30), ST-T or T-wave changes in 9 cases (30%, 9/30), and arrhythmia in 8 cases (27%, 8/30).
Conclusions: Cancer chemotherapy drugs to the heart may produce an immediate or long-term toxicity, in which could significantly effects on the survival and prognosis of patients. It is very important to prevent the occurrence of cardiotoxicity of chemotherapeutic drugs in gynecological cancer patients with heart diseases during chemotherapy.