Second-line therapies in hepatocellular carcinoma: emergence of resistance to sorafenib

Clin Cancer Res. 2012 Apr 1;18(7):1824-6. doi: 10.1158/1078-0432.CCR-12-0151. Epub 2012 Feb 21.

Abstract

Second-line therapies are needed for patients with advanced hepatocellular carcinoma who progress after sorafenib. Positive signals seen with brivanib in phase II studies, reported herein, have yet to be confirmed in phase III trials. Identification of the molecular mechanisms driving sorafenib resistance should guide drug development strategies in this setting.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alanine / analogs & derivatives*
  • Alanine / therapeutic use
  • Carcinoma, Hepatocellular / drug therapy*
  • Female
  • Humans
  • Liver Neoplasms / drug therapy*
  • Male
  • Triazines / therapeutic use*

Substances

  • Triazines
  • brivanib
  • Alanine