A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population

Jun Egawa; Yuichiro Watanabe; Ayako Nunokawa; Taro Endo; Naoshi Kaneko; Ryu Tamura; Toshiro Sugiyama; Toshiyuki Someya

doi:10.1016/j.psychres.2011.09.001

A detailed association analysis between the tryptophan hydroxylase 2 (TPH2) gene and autism spectrum disorders in a Japanese population

Psychiatry Res. 2012 Apr 30;196(2-3):320-2. doi: 10.1016/j.psychres.2011.09.001. Epub 2012 Feb 22.

Authors

Jun Egawa¹, Yuichiro Watanabe, Ayako Nunokawa, Taro Endo, Naoshi Kaneko, Ryu Tamura, Toshiro Sugiyama, Toshiyuki Someya

Affiliation

¹ Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

PMID: 22361444
DOI: 10.1016/j.psychres.2011.09.001

Abstract

We conducted a detailed association analysis between the tryptophan hydroxylase 2 gene and autism spectrum disorders in a Japanese population using 19 markers, including tagging single nucleotide polymorphisms and a novel missense variation, p.R225Q, identified through exon resequencing. However, we failed to obtain supportive evidence for an association.

MeSH terms

Adolescent
Adult
Asian People / genetics*
Child
Child Development Disorders, Pervasive / diagnosis
Child Development Disorders, Pervasive / epidemiology
Child Development Disorders, Pervasive / genetics*
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease / genetics*
Genotype
Humans
Japan / epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Tryptophan Hydroxylase / genetics*
Young Adult

Substances

TPH2 protein, human
Tryptophan Hydroxylase