Assessment of additional endpoints for trials in acute stroke - what, when, where, in who?

Int J Stroke. 2012 Apr;7(3):227-30. doi: 10.1111/j.1747-4949.2012.00773.x.

Abstract

Functional outcome in acute stroke trials among others is usually measured on the modified Rankin Scale. However, new onset of depression, cognitive decline, and communication deficits alone or in combination affect more than 25% of patients. This report summarizes the findings and conclusions of a workshop by the European Stroke Organization held in February 2011 We propose that assessment of mood disorders, cognitive impairment/dementia, language or communication dysfunction, and quality of life should supplement outcome measures after acute stroke.

MeSH terms

  • Clinical Trials as Topic
  • Cognition Disorders / diagnosis
  • Cognition Disorders / psychology
  • Cognition Disorders / therapy
  • Depression / diagnosis
  • Depression / psychology
  • Depression / therapy
  • Endpoint Determination / methods*
  • Humans
  • Mood Disorders / diagnosis
  • Mood Disorders / psychology
  • Mood Disorders / therapy
  • Quality of Life / psychology*
  • Stroke / diagnosis
  • Stroke / psychology*
  • Stroke / therapy*