Context: Colloid carcinoma is considered a distinct type of pancreatic neoplasia with specific histopathological and molecular features, and a better prognosis.
Case report: We present the case of a patient with a 15 cm locally invasive colloid carcinoma of the pancreas, in which an aggressive surgical approach achieved no evidence of disease 24 months after surgery.
Conclusions: If an accurate diagnostic approach and surgical resection are performed, the 5-year survival rate can reach 60%. Presence of invasive intraductal papillary mucinous neoplasm has been reported, and this can affect the prognosis. Adjuvant therapy has not demonstrated improvement of survival in surgically-resected patients.