The immune contexture in human tumours: impact on clinical outcome

Wolf Herman Fridman; Franck Pagès; Catherine Sautès-Fridman; Jérôme Galon

doi:10.1038/nrc3245

The immune contexture in human tumours: impact on clinical outcome

Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.

Authors

Wolf Herman Fridman¹, Franck Pagès, Catherine Sautès-Fridman, Jérôme Galon

Affiliation

¹ INSERM UMRS872, Laboratory of Immune microenvironment and tumours, Paris F75006, France.

PMID: 22419253
DOI: 10.1038/nrc3245

Abstract

Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chemokines / metabolism
Cytokines / metabolism
Disease-Free Survival
Humans
Mice
Molecular Targeted Therapy
Neoplasms / drug therapy
Neoplasms / immunology*
Neoplasms / metabolism
Neoplasms / pathology
Prognosis
Tumor Microenvironment
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Vascular Endothelial Growth Factor A / metabolism

Substances

Chemokines
Cytokines
VEGFA protein, human
Vascular Endothelial Growth Factor A