False-negative hepatitis B virus (HBV) surface antigen in a vaccinated dialysis patient with a high level of HBV DNA in the United States

Clin Vaccine Immunol. 2012 May;19(5):820-2. doi: 10.1128/CVI.05696-11. Epub 2012 Mar 21.

Abstract

Screening with hepatitis B surface antigen (HBsAg) is highly recommended for at-risk individuals. Mutations in the HBsAg can result in an inability to detect the virus during routine screening. We describe a hemodialysis patient found to have high levels of hepatitis B virus (HBV) DNA and HBV antibody but negative HBsAg on two routine assays.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • DNA, Viral / blood*
  • False Negative Reactions*
  • Female
  • Hepatitis B / diagnosis*
  • Hepatitis B / virology*
  • Hepatitis B Antibodies / blood
  • Hepatitis B Surface Antigens / blood*
  • Hepatitis B virus / isolation & purification*
  • Humans
  • Middle Aged
  • Renal Dialysis / adverse effects*
  • United States

Substances

  • DNA, Viral
  • Hepatitis B Antibodies
  • Hepatitis B Surface Antigens