Metformin, metabolic stress, and mitochondria. Focus on "A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells"

Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C1-3. doi: 10.1152/ajpcell.00090.2012. Epub 2012 Mar 21.
No abstract available

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Glucose / pharmacology*
  • Humans
  • Metformin / pharmacology*
  • Sirtuin 1 / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Metformin
  • AMP-Activated Protein Kinases
  • SIRT1 protein, human
  • Sirtuin 1
  • Glucose