Abstract
Over the past decade, several longitudinal epidemiological studies have brought attention to the haptoglobin genotype and its importance in determining diabetic vascular disease risk. This manuscript presents an overview of the biology of the haptoglobin genotype and reviews the literature concerning its role in the development of cardiovascular disease among individuals with diabetes mellitus.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cardiovascular Diseases / epidemiology
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Cardiovascular Diseases / genetics*
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Cardiovascular Diseases / immunology
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Diabetes Complications / epidemiology
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Diabetes Complications / genetics*
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Diabetes Complications / immunology
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Diabetes Mellitus / epidemiology
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Diabetes Mellitus / genetics*
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Diabetes Mellitus / immunology
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Diabetic Angiopathies / epidemiology
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Diabetic Angiopathies / genetics*
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Diabetic Angiopathies / immunology
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Genetic Predisposition to Disease
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Haptoglobins / chemistry
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Haptoglobins / genetics*
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Haptoglobins / metabolism
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Humans
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Incidence
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Phenotype
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Polymorphism, Genetic*
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Prognosis
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Protein Conformation
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Risk Assessment
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Risk Factors
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Structure-Activity Relationship
Substances
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HP protein, human
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Haptoglobins