Abstract
In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo- and enantiocontrol (up to 99% ee).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Anhydrides / chemistry*
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Catalysis
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Cinchona Alkaloids / chemistry
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Combinatorial Chemistry Techniques
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Isocoumarins / chemical synthesis*
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Isocoumarins / chemistry
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Molecular Structure
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Stereoisomerism
Substances
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Aldehydes
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Anhydrides
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Cinchona Alkaloids
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Isocoumarins