The bone surrounding a prosthetic implant normally experiences a progressive quantitative reduction as a result of stress shielding and wear debris production, that can lead to the aseptic loosening of the implant. Dual-energy X-ray absorptiometry (DXA), using software algorithms, can ensure a surrogate measure of load redistribution after the implant of the prosthetic components and can be a valid tool to evaluate the efficacy of pharmacological therapy to reduce the periprosthetic bone loss. In several animal and human studies DXA has been able to quantify antiresorptive action of bisphosphonates in the periprosthetic area.