Diastereoselective alkylation reactions of 1-methylcyclohexa-2,5-diene-1-carboxylic acid

Org Biomol Chem. 2012 May 21;10(19):3859-65. doi: 10.1039/c2ob25211b. Epub 2012 Apr 4.

Abstract

The deprotonation and alkylation of 1-methylcyclohexa-2,5-diene-1-carboxylic acid has been investigated under a range of conditions. In all cases, the formation of compounds 14 was found to be completely stereoselective, although compound 14c was formed as an impurity when alkyl iodides were used as electrophiles, and doubly-alkylated compounds 17 were formed in some cases when alkyl bromides were used.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Cyclohexanecarboxylic Acids / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Stereoisomerism

Substances

  • Cyclohexanecarboxylic Acids