1q21 amplification with additional genetic abnormalities but not isolated 1q21 gain is a negative prognostic factor in newly diagnosed patients with multiple myeloma treated with thalidomide-based regimens

MeSH terms

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
• Chromosome Aberrations*
• Chromosome Deletion
• Chromosomes, Human, Pair 1 / genetics*
• Chromosomes, Human, Pair 13 / genetics
• Chromosomes, Human, Pair 14 / genetics
• Chromosomes, Human, Pair 17 / genetics
• Chromosomes, Human, Pair 4 / genetics
• Female
• Gene Amplification
• Humans
• In Situ Hybridization, Fluorescence
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multiple Myeloma / diagnosis
• Multiple Myeloma / drug therapy*
• Multiple Myeloma / genetics*
• Prognosis
• Thalidomide / administration & dosage
• Translocation, Genetic