Abstract
Non-alcoholic fatty liver disease encompasses a spectrum ranging from simple steatosis to steatohepatitis without excess alcohol intake and is considered to be the hepatic manifestation of metabolic syndrome. Recent studies indicate that non-alcoholic fatty liver disease is closely related to cardiovascular disease, especially to thickening of the intima-media layer of the carotid artery, as the morphostructural manifestation of the presence of subclinical atheromatosis. Therefore, the correct management of non-alcoholic fatty liver disease would allow the natural history of both the liver disease and the atherosclerosis to be modified.
Copyright © 2012 Elsevier España, S.L. and AEEH y AEG. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apolipoprotein C-III / genetics
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Atherosclerosis / epidemiology*
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Atherosclerosis / metabolism
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Cardiovascular Diseases / epidemiology*
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Cardiovascular Diseases / etiology
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / prevention & control
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Carotid Intima-Media Thickness
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Cholesterol, LDL / metabolism
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Comorbidity
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Diabetes Mellitus, Type 2 / epidemiology
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Dyslipidemias / epidemiology
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Dyslipidemias / metabolism
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Fatty Liver / epidemiology*
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Fatty Liver / genetics
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Fatty Liver / metabolism
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Humans
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Hyperhomocysteinemia / epidemiology
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Insulin Resistance
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Lipase / genetics
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Membrane Proteins / genetics
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Metabolic Syndrome / epidemiology*
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Metabolic Syndrome / metabolism
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Non-alcoholic Fatty Liver Disease
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Obesity / epidemiology
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Risk Factors
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Smoking / adverse effects
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Smoking / epidemiology
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Triglycerides / metabolism
Substances
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Apolipoprotein C-III
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Cholesterol, LDL
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Membrane Proteins
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Triglycerides
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Lipase
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adiponutrin, human