[Influence of non-alcoholic fatty liver disease on cardiovascular disease]

Gastroenterol Hepatol. 2012 Oct;35(8):585-93. doi: 10.1016/j.gastrohep.2012.02.005. Epub 2012 Apr 26.
[Article in Spanish]

Abstract

Non-alcoholic fatty liver disease encompasses a spectrum ranging from simple steatosis to steatohepatitis without excess alcohol intake and is considered to be the hepatic manifestation of metabolic syndrome. Recent studies indicate that non-alcoholic fatty liver disease is closely related to cardiovascular disease, especially to thickening of the intima-media layer of the carotid artery, as the morphostructural manifestation of the presence of subclinical atheromatosis. Therefore, the correct management of non-alcoholic fatty liver disease would allow the natural history of both the liver disease and the atherosclerosis to be modified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apolipoprotein C-III / genetics
  • Atherosclerosis / epidemiology*
  • Atherosclerosis / metabolism
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / prevention & control
  • Carotid Intima-Media Thickness
  • Cholesterol, LDL / metabolism
  • Comorbidity
  • Diabetes Mellitus, Type 2 / epidemiology
  • Dyslipidemias / epidemiology
  • Dyslipidemias / metabolism
  • Fatty Liver / epidemiology*
  • Fatty Liver / genetics
  • Fatty Liver / metabolism
  • Humans
  • Hyperhomocysteinemia / epidemiology
  • Insulin Resistance
  • Lipase / genetics
  • Membrane Proteins / genetics
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / metabolism
  • Non-alcoholic Fatty Liver Disease
  • Obesity / epidemiology
  • Risk Factors
  • Smoking / adverse effects
  • Smoking / epidemiology
  • Triglycerides / metabolism

Substances

  • Apolipoprotein C-III
  • Cholesterol, LDL
  • Membrane Proteins
  • Triglycerides
  • Lipase
  • adiponutrin, human