Circulating endothelial progenitors and tumor resistance to vascular-targeting therapies

Cancer Discov. 2012 May;2(5):395-7. doi: 10.1158/2159-8290.CD-12-0137.

Abstract

Acute mobilization of circulating endothelial progenitors has been implicated in tumor resistance to vascular-disrupting agents. In the current issue of Cancer Discovery, Taylor and colleagues provide novel insight into the kinetics of endothelial progenitor mobilization by vascular-disrupting agents in both mouse tumor models and cancer patients.

Publication types

  • Comment

MeSH terms

  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Drug Resistance, Neoplasm*
  • Endothelial Cells / drug effects*
  • Humans
  • Male
  • Stem Cells / drug effects*

Substances

  • Angiogenesis Inhibitors