Abstract
Aetheramides are structurally distinctive cyclic peptides isolated from a novel myxobacterial genus proposed to be termed "Aetherobacter". The structures were solved by a combination of NMR analyses, quantum mechanical calculations, and chemical derivatizations. Aetheramides which contain a unique polyketide moiety and two amino acid residues potently inhibited HIV-1 infection with IC(50) values of ~0.015 μM. Furthermore aetheramides showed cytostatic activity against human colon carcinoma (HCT-116) cells with IC(50) values of 0.11 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology*
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification*
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Depsipeptides / pharmacology*
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Drug Screening Assays, Antitumor
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HCT116 Cells
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HIV-1 / drug effects*
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Humans
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Molecular Structure
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Myxococcales / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Anti-HIV Agents
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Antineoplastic Agents
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Depsipeptides
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aetheramide A
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aetheramide B