Universal HIV testing in London tuberculosis clinics: a cluster randomised controlled trial

Eur Respir J. 2013 Mar;41(3):627-34. doi: 10.1183/09031936.00034912. Epub 2012 Jun 14.

Abstract

We assessed whether implementation of a combination of interventions in London tuberculosis clinics raised the levels of HIV test offers, acceptance and coverage. A stepped-wedge cluster randomised controlled trial was conducted across 24 clinics. Interventions were training of clinical staff and provision of tailor-made information resources with or without a change in clinic policy from selective to universal HIV testing. The primary outcome was HIV test acceptance amongst those offered a test, before and after the intervention; the secondary outcome was an offer of HIV testing. Additionally, the number and proportion of HIV tests among all clinic attendees (coverage) was assessed. 1,315 patients were seen in 24 clinics. The offer and coverage of testing rose significantly in clinics without (p = 0.002 and p = 0.004, respectively) and with an existing policy of universal testing (p = 0.02 and p = 0.04, respectively). However, the level of HIV test acceptance did not increase in 18 clinics without routine universal testing (p = 0.76) or the six clinics with existing universal testing (p = 0.40). The intervention significantly increased the number of HIV tests offered and proportion of participants tested, although acceptance did not change significantly. However, the magnitude of increase is modest due to the high baseline coverage.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Ambulatory Care Facilities
  • Communicable Disease Control / methods*
  • Female
  • HIV Infections / complications*
  • HIV Infections / diagnosis*
  • Humans
  • London
  • Male
  • Mass Screening / methods*
  • Middle Aged
  • Models, Statistical
  • Patient Acceptance of Health Care
  • Treatment Outcome
  • Tuberculosis / complications*
  • Tuberculosis / therapy*
  • Young Adult