Malignant transformation of bronchogenic cyst revealed by 99mTc-MIBI-SPECT

Asian Cardiovasc Thorac Ann. 2012 Jun;20(3):347-9. doi: 10.1177/0218492311436258.

Abstract

Adenocarcinoma arising from a mediastinal cyst was detected by exercise technetium-99m hexakis-2-methoxyisobuty-lisonitrile (99m)Tc-MIBI scintigraphy in a 65-year-old woman with known coronary disease. This guided further investigations and resection of the tumor which stained positive for P-glycoprotein. Three years earlier, myocardial scintigraphy was negative, probably due to down-expression of P-glycoprotein because the cells were in the early stages of carcinogenesis. After completing malignant transformation, the high P-glycoprotein expression resulted in MIBI uptake on the second myocardial scintigraphy.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / analysis
  • Adenocarcinoma / chemistry
  • Adenocarcinoma / diagnostic imaging*
  • Adenocarcinoma / surgery
  • Aged
  • Biomarkers, Tumor / analysis
  • Biopsy, Fine-Needle
  • Bronchogenic Cyst / diagnostic imaging*
  • Cell Transformation, Neoplastic / metabolism
  • Cell Transformation, Neoplastic / pathology*
  • Coronary Artery Disease / diagnostic imaging*
  • Exercise Test
  • Female
  • Humans
  • Immunohistochemistry
  • Incidental Findings
  • Mediastinal Neoplasms / chemistry
  • Mediastinal Neoplasms / diagnostic imaging*
  • Mediastinal Neoplasms / surgery
  • Predictive Value of Tests
  • Radiopharmaceuticals*
  • Technetium Tc 99m Sestamibi*
  • Tomography, Emission-Computed, Single-Photon*
  • Tomography, X-Ray Computed

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Biomarkers, Tumor
  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi