Identification of a G-CSF-Granulocytic MDSC axis that promotes tumor progression

Oncoimmunology. 2012 Jul 1;1(4):550-551. doi: 10.4161/onci.19334.

Abstract

Myeloid-derived suppressor cells (MDSC) induced during neoplasia display potent pro-tumorigenic activities. Tumor-derived factors influence MDSC development, yielding monocytic and granulocytic subsets. In contrast to monocytic MDSC, little is known about how granulocytic MDSC develop. We demonstrated that tumor-derived G-CSF drives granulocytic MDSC formation, thus providing new insights into myeloid-tumor biology.