Itch and the brain

Chem Immunol Allergy. 2012:98:253-65. doi: 10.1159/000336529. Epub 2012 Jun 26.

Abstract

The sensation of itch - defined as unpleasant sensation inducing the urge to scratch - is processed by a network of different brain regions contributing to the encoding of sensory, emotional, attention-dependent, cognitive-evaluative and motivational patterns. Patients with atopic eczema show different activation patterns and kinetics compared to healthy volunteers. This review summarizes current studies investigating itch in the brain.

Publication types

  • Review

MeSH terms

  • Brain / anatomy & histology
  • Brain / diagnostic imaging*
  • Brain / metabolism
  • Dermatitis, Atopic / diagnostic imaging
  • Dermatitis, Atopic / metabolism
  • Histamine / metabolism
  • Humans
  • Magnetic Resonance Imaging
  • Neuroimaging
  • Positron-Emission Tomography
  • Pruritus / diagnostic imaging*
  • Pruritus / metabolism
  • Temperature

Substances

  • Histamine