Screening for Chlamydia trachomatis using self-collected vaginal swabs at a public pregnancy termination clinic in France: results of a screen-and-treat policy

Sex Transm Dis. 2012 Aug;39(8):622-7. doi: 10.1097/OLQ.0b013e318254ca6f.

Abstract

Objective: To assess the prevalence of Chlamydia trachomatis (CT) infection and the risk factors for CT infection among women presenting for abortion at a clinic in France.

Methods: Women seeking surgically induced abortions were systematically screened by PCR on self-collected vaginal swabs between January 1, 2010, and September 30, 2010. CT-positive women were treated with oral azithromycin (1 g) before the surgical procedure.

Results: Of the 978 women included in the study, 66 were CT positive. The prevalence was 6.7% (95% confidence intervals [CI] 5.1%-8.3%). The risk factors for CT infection were the following: age <30 years (Odds ratio [OR]: 2.0 [95% CI: 1.2-3.5]), a relationship status of single (OR: 2.2 [95% CI: 1.2-4.0]), having 0 or 1 child (OR: 5.2 [95% CI: 2.0-13.0]), not using contraception (OR: 2.4 [95% CI: 1.4-4.1]), and completing 11 weeks or more of gestation (OR: 2.1 [95% CI: 1.3-3.6]). Multiple logistic regression indicated that 4 factors--having 0 or 1 child, a single relationship status, no contraceptive use, and a gestation of 11 weeks or more--were independently associated with CT infection. The rate of postabortion infection among all patients was 0.4% (4/978).

Conclusions: These results reveal a high prevalence (6.7%) of CT-positive patients among French women seeking induced abortions. Because it is not common practice to screen the general population for CT, screening before induced abortions seems relevant. A cost-effectiveness study is required to evaluate this screen-and-treat policy.

MeSH terms

  • Abortion, Induced / statistics & numerical data*
  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Azithromycin / administration & dosage*
  • Chlamydia Infections / diagnosis
  • Chlamydia Infections / drug therapy
  • Chlamydia Infections / epidemiology*
  • Chlamydia trachomatis / isolation & purification*
  • Female
  • France / epidemiology
  • Health Policy
  • Humans
  • Mass Screening*
  • Pregnancy
  • Prevalence
  • Referral and Consultation
  • Retrospective Studies
  • Sentinel Surveillance
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Azithromycin