Galactomannan enzymatic immunoassay cross-reactivity caused by Prototheca species

D Van den Bossche; A De Bel; M Hendrickx; A De Becker; R Jacobs; A Naessens; D Piérard

doi:10.1128/JCM.01028-12

Galactomannan enzymatic immunoassay cross-reactivity caused by Prototheca species

J Clin Microbiol. 2012 Oct;50(10):3371-3. doi: 10.1128/JCM.01028-12. Epub 2012 Jul 25.

Authors

D Van den Bossche¹, A De Bel, M Hendrickx, A De Becker, R Jacobs, A Naessens, D Piérard

Affiliation

¹ Department of Microbiology and Infection Control, Universiteit Brussel, Brussels, Belgium.

Abstract

We report a reactive Aspergillus galactomannan enzymatic immunoassay against the serum of a patient with invasive Prototheca zopfii infection. Analysis of the supernatants of suspensions of P. zopfii and other Prototheca isolates revealed positive results as well. These data suggest cross-reactivity with the serum Aspergillus galactomannan assay in invasive protothecosis.

Publication types

Case Reports

MeSH terms

Aspergillus / immunology*
Clinical Laboratory Techniques / methods*
Cross Reactions*
DNA, Fungal / chemistry
DNA, Fungal / genetics
Galactose / analogs & derivatives
Humans
Immunoenzyme Techniques / methods
Male
Mannans / blood*
Middle Aged
Molecular Sequence Data
Mycoses / diagnosis*
Mycoses / microbiology
Mycoses / pathology
Prototheca / immunology*
Sensitivity and Specificity
Sequence Analysis, DNA

Substances

DNA, Fungal
Mannans
galactomannan
Galactose

Associated data

GENBANK/JQ679396