Ruthenium-catalyzed oxidative C(sp2)-H bond hydroxylation: site-selective C-O bond formation on benzamides

Org Lett. 2012 Aug 17;14(16):4210-3. doi: 10.1021/ol3018819. Epub 2012 Aug 2.

Abstract

Well-defined ruthenium carboxylate complexes enabled unprecedented ruthenium-catalyzed C(sp(2))-H hydroxylations on benzamides with PhI(OAc)(2) as the oxidant at a remarkably low catalyst loading of 1.0 mol %.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzamides / chemical synthesis*
  • Benzamides / chemistry
  • Carboxylic Acids / chemistry
  • Catalysis
  • Hydroxylation
  • Molecular Structure
  • Oxidation-Reduction
  • Ruthenium / chemistry*

Substances

  • Benzamides
  • Carboxylic Acids
  • Ruthenium