Radiosynthesis of [11C]SNAP-7941--the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1)

Appl Radiat Isot. 2012 Oct;70(10):2287-94. doi: 10.1016/j.apradiso.2012.07.010. Epub 2012 Jul 20.

Abstract

The melanin concentrating hormone (MCH) system is a new target to treat human disorders. Our aim was the preparation of the first PET-tracer for the MCHR1. [(11)C]SNAP-7941 is a carbon-11 labeled analog of the published MCHR1 antagonist SNAP-7941. The optimum reaction conditions were 2 min reaction time, ≤25°C reaction temperature, and 2 mg/mL precursor (SNAP-acid) in acetonitrile, using [(11)C]CH(3)OTf as methylation agent. [(11)C]SNAP-7941 was prepared in a reliable and feasible manner with high radiochemical yields (2.9±1.6 GBq; 11.5±6.4% EOB, n=15).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Radioisotopes / chemistry*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Piperidines / chemical synthesis*
  • Positron-Emission Tomography*
  • Pyrimidines / chemical synthesis*
  • Quality Control
  • Receptors, Somatostatin / metabolism*

Substances

  • Carbon Radioisotopes
  • Mchr1 protein, mouse
  • Piperidines
  • Pyrimidines
  • Receptors, Somatostatin
  • SNAP7941